Keyword coriolus versicolor

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In this article, Professor Vittorio Calabrese explains the role that the mushrooms Coriolus versicolor and Hericium erinaceus may play in inhibiting the progression of diseases related to oxidative stress such as dementia or early Alzheimer's disease. The role of this mushrooms comes from upregulating LXA4 a protein in the brain cells membrane that will stimulate certain systems within our body to reduce these oxidative species.

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Besides nutritional properties, mushrooms have attracted market attention because they are a potential source of bioactive compounds able to perform several functions in organisms with benefits for consumer health. In recent years Coriolus versicolor aroused interest among researchers because of the bioactive properties demonstrated.
Polysaccharopeptide (PSP) and polysaccharopeptide Krestin (PSK) have shown to be useful adjuncts to the therapy of cancer; these polysaccharides from C. versicolor have also shown prebiotic activity, stimulating the growth of probiotic bacteria. This review article highlights the health-promoting potential of several mushroom species with special emphasis on C. versicolor.

(1) Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina – Laboratório Associado, Escola Superior de Biotecnologia, Rua Arquiteto Lobão Vital, Apartado 2511, 4202-401 Porto, Portugal

(2) Centro de Investigación en Recursos Naturales y Sustentabilidad (CIRENYS), Universidad Bernardo O’Higgins, Fábrica N∘ 1990, Segundo Piso, Santiago, Chile

(3) CEIL, Lúrio University, Marrere, Nampula, Mozambique


Journal of Food and Nutrition Research. Vol. 4, No. 12, 2016, pp 773-781

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Results indicate that nutritional modulation of critical proteins involved in brain stress tolerance can be achieved via supplementation with a well characterized strain of C. versicolor biomass. These findings are relevant to those theories connecting faulty protein quality control mechanisms with age-associated neurodegenerative diseases

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There is a body of thought that viruses such as the herpes simplex virus (HSV-1) is a contributing factor in the development of Alzheimer´s disease. In addition, Dr LaFerla at the University of California has suggested the activation of Lipoxin A4 (LXA4) could reduce the progress of (or delay the onset of) Alzheimer´s disease. This article provides the rationale for the use of mushroom nutrition (in the form of a combination of Coriolus versicolor and Hericium erinaceus (biomass)), to provide both anti-viral protection and activation of LXA4.

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(tchernev@safesex.bg)

This poster was presented at the 3rd Congress of Gynecologists and obstetricians of Macedonia (with International Participation) from May 16th to 19th, 2013, Orhid, Macedonia.

Conclusion: Coriolus-MRL has no adverse reactions and drug interactions with the main drugs used for the treatment and it could be taken during pregnancy. It is an addition to the methods for prevention and treatment (both combined and conservative) of HPV infection.

1 University Hospital of Obstetrics and Gynecology-Sofia, Bulgaria.

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(Jsilvacouto@netcabo.pt)

This poster was presented at the 14th World Congress of Cervical Pathology and Coloscopy, July 4-7, 2011 in Rio de Janeiro, Brazil

Conclusion: The use of Coriolus versicolor for one year revealed a great efficacy, whether in the regression of the displasia (LSIL) or in the disappearance of the High Risk HPV. It seems therefore, to be a very useful food supplementation with positive therapeutic impact, either in the reversion of LSIL (with High Risk HPV+), or in those HSIL patients, who have undergone surgery but experience continued High Risk HPV viral count.


1 Gynaecology Department-Portuguese Institute of Oncology-Cervical Pathology Unit, Coimbra, Portugal
2 CEF/Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal

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The main outcome was to study the mean rate of change in Natural Killer Cell Activity in patients who have undergone conventional breast cancer protocol: chemotherapy followed by radiotherapy in which there is a subseqent decrease in Natural Killer Cell Activity. The study was funded by CTRF and was halted as naturopaths were unable to recruit patients for the study. The attachments outline the rational for the study along with timeline.

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The attached is the English translation of the following 2008 Medline article: Akush Ginekol (Sofiia). 2008;47 Suppl 3:51-3. [Coriolus versicolor—innovation in prevention of oncogynecological diseases, especially HPV]. [Article in Bulgarian]
Bogdanova J.

Abstract: Coriolus-MRL is a nutrient adjuvant, which contains biomass of the fungus Coriolus versicolor and is studied to reverse early stages of cervical cancer and to reduce risk factors of reoccurring HPV virus. PMID:19449722
[PubMed - indexed for MEDLINE]

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(http://www.breakspearmedical.com)

Journal of Integrative Medicine 2004;8:101-108

In this article Dr. Jean Monro of Breakspear Hospital, has demonstrated in a group of 36 patients who have had defined chronic fatigue syndrome and autonomic dysfunction that Coriolus MRL has been an immuno-therapeutic agent. It has improved natural killer cells numbers by 35% in this group with a two months course of treatment.

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Archives of Environmental Health, August 2003 (Vol. 58 (No.8 )). Reprinted with permission of the Helen Dwight Reid Educational Foundation. Published by Heldref Publications, 1319 18th Street, NW, Washington, DC 20036-1802. Copyright � (2004).

In this article Dr. Monro points discusses how 20% of all cancers are triggered by viral infections. Dr. Monro outlines that having provided 30 Chronic Fatigue Syndrome patients Coriolus-MRL supplementation over eight weeks, there were significant improvements in the overall immune systems of the majority of the patients and that Coriolus supplementation could be utilized as a preventative immunutrition for those patients with such viral conditions that could develop into more serious oncological conditions i.e. HPV infection or Epstein Barr infection. Dr. Monro also outlines that Coriolus supplementation not only increases Natural Killer cell activity by 35%, but may also play a role in facilitating intercellular communication, thereby allowing the immune system to operate more effectively.

For more information on Heldref Publications and the Archives of Environmental Health, see the following link http://www.heldref.org

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Presented at the 10th International Congress of Mucosal Immunology in Amsterdam, June 28th - July 1st, 1999.

This curiosity outlines the impact of Coriolus versicolor supplementation on the White Blood Count (WBC) in three HIV positive patients at the following intervals of supplementation: Days 1-15 at 3.0 grams per day; Days 16-45 at 1.5 grams per day. Results: a 45% increase in WBC over 45 days.

To Contact Dr. Grazia Rotolo, please contact grotolo@venus.it

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Presented at the 10th International Congress of Mucosal Immunology in Amsterdam, June 28th - July 1st, 1999.

This curiosity outlines the impact of Coriolus supplementation (6.0 grams per day to 9.0 grams per day) on the CD4 levels and viral load levels of three (3) Kaposi sarcoma patients. Results: For Kaposi sarcoma patients, Coriolus versicolor supplementation at 6.0 grams per day to 9.0 grams per day can significantly increase CD4 levels and provide a better quality of life.

To Contact Mr John Tindall please contact Yuan Clinic at:
Yuan Clinic
c/o Green Healer7 Clapham High Street
London SW4 7TS
United Kingdom

Tel/Fax:+44-207-622-9079.

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Presented at the III International Symposium on Mushroom Nutrition in Milan on Saturday, March 10th, 2001.

This case study outlines the changes in CD4 levels and viral loads of eight (8) HIV+ patients on Coriolus versicolor supplementation levels of 1.5 grams per day over a twelve (12) month period. Results: Coriolus versicolor supplementation as low as 1.5 grams per day can increase CD4 levels and decrease viral loads in HIV+ patients. For similar impact in post-HAART patients the supplementation levels must be at 3.0 grams per day.

To contact Ms. Marijke Pfeiffer
Centrum Voor Integrale GeneeskundesAmsterdam, The Netherlands

Fax:31-20-624-9710

Email: cig@xs4all.nl

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In this case study on the use of Coriolus versicolor in fifteen (15) patients with Chronic Fatigue Syndrome, Dr. Monro measures the increase in Natural Killer Cell (NK) activity over 45 days when Coriolus supplementation is given at 3.0 grams for fifteen (15) days and then decreased to 1.5 grams for thirty (30) days. Results: Coriolus supplementation increased NK cell activity significantly in Chronic Fatigue Syndrome patients.

To contact Dr.Jean Monro at Breakspear Hospital

Tel:44-1442-261-333 / Fax:44-1442-266-388

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Presented at the 2nd International Symposium on HPV and Cancer, in Lisbon Portugal on May 26th, 2001.

This prospective trial design outlines the rational for the use of Coriolus versicolor supplementation (3.0 grams per day) to improve the immune system in HPV infected women in order to control the stage of HPV development. Dr. Monro is the first to suggest that Coriolus versicolor supplementation may reverse a Th1 to Th2 shift in the immune system.

To contact Dr.Jean Monro at Breakspear Hospital

Tel:44-1442-261-333 / Fax:44-1442-266-388

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Presented at the 4th International Symposium on Mushroom Nutrition, University of Westminster, June 15th, 2002.

Professor Lorite gives a Traditional Chinese Medicine (TCM) perspective on the reason that women having Chronic Fatigue Syndrome over a long period of time may suffer from breast lumps / myomas. She provides suggestions for treatment from a TCM perspective that includes acupuncture, herbs and Coriolus versicolor supplementation.

To contact Professor Nuria Lorite
Centro BilobaC/ Santa Clara, 4128200 San Lorenzo de El EscorialMadrid Spain

Tel.: +34 650 43 90 91

Email: nurialoriteayan@gmail.com

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Presented at the 5th International Symposium on Mushroom Nutrition, University of Westminster, June 14th, 2002.

This abstract outlines the impact of using 4.5 grams per day of Coriolus versicolor supplementation in a breast cancer patient undergoing chemotherapy. The case study outlines the significant impact of Coriolus supplementation on immune parameters and on the quality of life for the patient.

To contact Dra. Ana Ferro / Paula Boaventura
Clinica de Saúde Integral
Rua Constitução, 1959-loja A 4250 / 170 Porto, Portugal

Tel:351-22-832-80-47 / Fax:351-22-832-80-49

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This study of increasing Coriolus versicolor supplementation (4.5 grams per day to 13.0 grams per day over a 90 day period) measures the impact of such supplementation on telomerase activity, interleukin 5, interleukin 12 and Tumour Necrosis Factor Beta over 120 days. Results were a significant decrease in teleomerase and interleukin-12 activity, followed by a significant increase in interleukin-5 activity within 120 days.

Presented at the 5th International Symposium on Mushroom Nutrition, University of Westminster, June 14th, 2002.