The accumulation of β-amyloid plaques, neurofibrillary tangles, and neuroinflammation are key hallmarks of Alzheimer's disease (AD). Reactive oxygen species (ROS) act as major triggers and amplifiers of neuroinflammatory responses, contributing to immune dysregulation and neuronal damage. Despite extensive research, no effective therapy halts or reverses AD progression, emphasizing the need for alternative preventive strategies, including the use of natural compounds.
Keyword pleurotus ostreatus
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a) Applied Plant Science Division, Agri-Food & Bioscience Institute, Northern Ireland
b) Grosvenor Grammar School, Northern Ireland
c) Northern Ireland Public Health Laboratories, Department of Bacteriology, Belfast City, Northern Ireland
d) School of Biomedical Sciences, Centre for Molecular Sciences, University of Ulster, Northern Ireland
Complementary Therapies in Clinical Practice 15 (2009) 5-7
Antibiotic agents have been in widespread and largely effective therapeutic use since their discovery in the 20th century. However, with the emergence of multi-drug resistant pathogens now presents an increasing global challenge to both human and veterinary medicine. It is now widely acknowledged that there is a need to develop novel antimicrobial agents to minimize the threat of further antimicrobial resistance, With this in mind, a study was undertaken to examine the antimicrobial properties of aqueous extracts of “exotic” Shitake and Oyster mushrooms on a range of environmental and clinically important microorganisms.
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This poster presents strong scientific evidence that monoclonal antibodies raised against beta glucans from MRL´s Pleurotus ostreatus also recognize beta glucans from other MRL products which is very interesting regarding their tertiary structure. The importance of the tertiary structure of beta-glucans is due to the fact that all beta-glucans with anti-tumor activity exhibited this tertiary structure. (Presented at the 12th International Chemical and Biological Engineering Conference (CHEMPOR 2014), organized by the Department of Chemical Engineering of the Faculty of Engineering - University of Porto and Ordem dos Engenheiros (the Portuguese Engineers Association), held in Porto, Portugal, between the 10th and 12th of September, 2014