Despite considerable research, the etiology and pathogenesis of Ménière’s disease remains controversial and undefined, although usually associated with allergic, genetic, or trauma sources, and with viral infections and/or immune system-mediated mechanisms. With treatment still unknown, our attention is towards the eventual impact of complementary dietary interventions, synthesizing the recent knowledge of some edible mushrooms and preparations on Ménière’s disease, which is a lifelong condition that can develop at any age, but most commonly emerges between 40 and 60 years of age. It is demonstrated that the oral administration of a biomass preparation, with 3 g/day of the mushroom Coriolus versicolor for 2 to 6 months, on some 40 human Ménière’s disease patients reduced systemic oxidative stress and cellular stress response, decreased the number of crises and their duration, and the frequency of symptoms, improving the clinical grading of tinnitus severity.
The Coriolus versicolor used in this clinical study was supplied by Mycology Research Laboratories Ltd.
Clinical Articles
The following section outlines the clinical papers, posters and proposals that refer to the clinical use of MRL mushroom nutrition products. This information is for healthcare practitioners only and should not be provided to members of the general public.
Full Article
Clinical articles
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Chemical Composition of Trametes versicolor, Hericium erinaceus, and Pleurotus ostreatus Mushroom Biomass: Deciphering their Rich α-glucan Composition and Nutritional Value
Helena Araújo-Rodrigues, Manuela Amorim, Clara Sousa, Ana Sofia Salsinha, Sara Marçal, Victor de Freitas, Joao Bettencourt Relvas, Freni K. Tavaria,Manuela E. Pintado. Journal of Food Composition and Analysis 143 (2025) 107612. -
Supporting Neurologic Health with Mushroom Nutrition
Victoria Bell, Palmen Dimitrov and Tito Fernandes -
Impact of Gastrointestinal Tract on Mushroom Biomass: Deciphering Their Potential on Gut Microbiota Modulation.
Helena Araújo-Rodrigues, Ana Sofia Salsinha, João Bettencourt Relvas, Freni K. Tavaria, Manuela E. Pintado Presented at the the 10th International Human Microbiome Consortium (IHMC) Congress held on June 22-25, 2024 in Rome Italy. -
Redox Modulation of Meniere Disease by Coriolus Versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential.
Rosanna Di Paola, Rosalba Siracusa, Roberta Fusco, Marialaura Ontario, Gaetano Cammilleri, Licia Pantano, Maria Scuto, Mario Tomasello, Sestina Spanò, Angela Trovato Salinaro, Ali S. Abdelhameed, Vincenzo Ferrantelli, Antonio Arcidiacono, Tilman Fritsch, Gabriella Lupo, Anna Signorile, Luigi Maiolino, Salvatore Cuzzocrea, and Vittorio Calabrese.
Curr Neuropharmacol 2023 Dec 8. PMID: 38073105