While most research studies focus on the polysaccharide fractions of mushroom-fruiting bodies, this study investigates the neuroprotective potential of mushroom biomass (MB) from Trametes versicolor, Hericium erinaceus, and Pleurotus ostreatus considering the possible synergistic effects of different macromolecules found both in the total mushroom and fruiting bodies.

The neuroprotective potential of serum-available fractions and key gut microbiota-derived metabolites were evaluated in transgenic Caenorhabditis elegans models of Alzheimer’s disease by analyzing chemotactic behavior and paralysis onset.

The mushroom biomass used in this study were supplied by Mycology Research Laboratories Ltd.