(1) Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Catania, Italy
(2) Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy
(3) Faculty of Veterinary Medicine, Lisbon University, Portugal
(4) Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Bari, Italy
(5) Spinal Unit, Emergency Hospital “Cannizzaro”, Catania, Italy
(6) Department of Clinical and Experimental Medicine, School of Medicine, University of Catania, Catania, Italy

This paper discusses the emerging role of lipoxinA4 and inflammasome in neurodegeneration. In addition, the paper outlines the notion that low levels of stress can induce responses that may be protective against the pathogenic processes is a frontier area of neurobiological research focal to understanding and developing therapeutic approaches to neurodegenerative disorders. Herein, we discuss the potential therapeutic role of Coriolus versicolor, a mushroom (Coriolus-MRL), well known in China as Yun Zhi. We propose a potentially innovative treatment for AD and, possibly, other neurodegenerative conditions associated to neuroinflammation.