(1) Laboratory for Research on Biologically Compatible Compounds, Facility of Dental Medicine, University of Monastir, Rue Avicenne, Monsastir 5019, Tunisia.
(2) Department of Biomedical and Biotechnological Sciences, University of Catania, Torre Biologica, Via Santa sofia n. 97, 95125 Catania, Italia.
(3) Department of Medical and Surgery Sciences, University of Catania, 95125, Via Santa sofia n. 78, 95123 Catania Italy.
(4) Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Piazza G. Ceasre, 11, 70124, Bari Italy.
Received: 10 February 2020; Accepted 17 March 2020; Published: 20 March 2020
The in vitro study examined in pheochromocytoma 12 (PC12) cells, whether the biomass form of Hericium erinaceus could exert a protective effect against oxidative stress and apoptosis induced by di(2-ethylhexyl) phthalate (DEHP), a plasticizer known to cause neurotoxicity. The researchers demonstrated that pre-treatment with Hericium erinaceus significantly reduced in force DHEP induced cell death. The researchers further postulated that the protective effect may be attributed to Hericium erinaceus´ ability in:
a) reducing intracellular reactive oxygen species levels,
b) preserving the activity of respiratory complexes and
c) stabilizing the mitochondrial membrane potential.
Additionally, Hericium erinaceus pre-treatment significantly modulated Nrf2 and Nrf2-dependent vitagenes expression, preventing the increase of pro-apoptotic and the decrease of anti-apoptotic markers. Collectively the data provides evidence of new preventive nutritional strategy using Hericium erinaceus against DHEP-induced apoptosis in PC12 cells.
Mycology Research Laboratories Ltd provided the Hericium erinaceus for this study.
Link to study
https://www.mdpi.com/1422-0067/21/6/2138
Clinical Articles
The following section outlines the clinical papers, posters and proposals that refer to the clinical use of MRL mushroom nutrition products. This information is for healthcare practitioners only and should not be provided to members of the general public.
Full Article
Clinical articles
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Natural Compounds such as Hericium erinaceus and Coriolus versicolor Modulate Neuroinflammation, Oxidative Stress and Lipoxin A4 Expression in Rotenone-Induced Parkinson’s Disease in Mice
Marika Cordaro 1,†, Sergio Modafferi 2,†, Ramona D’Amico 3, Roberta Fusco 3, Tiziana Genovese 3, Alessio Filippo Peritore 3, Enrico Gugliandolo 4, Rosalia Crupi 4, Livia Interdonato 3, Davide Di Paola 3, Daniela Impellizzeri 3,*, Salvatore Cuzzocrea 3,5,*, Vittorio Calabrese 2,*, Rosanna Di Paola 4,‡ and Rosalba Siracusa 3,‡ -
Key Mechanisms and Potential Implications of Hericium erinaceus in NLRP3 Inflammasome Activation by Reactive Oxygen Species during Alzheimer’s Disease
Marika Cordaro 1,† , Angela Trovato Salinaro 2,† , Rosalba Siracusa 3,† , Ramona D’Amico 3 , Daniela Impellizzeri 3 , Maria Scuto 2 , Maria Laura Ontario 2, Salvatore Cuzzocrea 3 , Rosanna Di Paola 3,* , Roberta Fusco 3,‡ and Vittorio Calabrese 2,‡ -
Coriolus Versicolor Downregulates TLR4/NF-B Signaling Cascade in Dinitrobenzenesulfonic Acid-Treated Mice: A Possible Mechanism for the Anti-Colitis Effect
Daniela Impellizzeri 1,† , Roberta Fusco 2,† , Tiziana Genovese 1, Marika Cordaro 3 , Ramona D’Amico 1 , Angela Trovato Salinaro 4 , Maria Laura Ontario 4, Sergio Modafferi 4, Salvatore Cuzzocrea 1,5,* , Rosanna Di Paola 6,* , Vittorio Calabrese 4,‡ and Rosalba Siracusa 1,‡ -
Characterization of bioactive compounds in mushroom biomass of Coriolus versicolor, Hericium erinaceus and Pleurotus ostreatus species
Helena Araújo-Rodrigues, Manuela Amorim, Ana Sofia Salsinha, Sara Marçal, Freni K. Tavaria, João B. Relvas and Manuela E. Pintado. Catolica University, Porto Portugal. Presented at the XXII Congress, European Food ChMemistry Congress (EuroFoodChem) June 14-16, 2023, Belgrade, Serbia.