(1) Laboratory for Research on Biologically Compatible Compounds, Facility of Dental Medicine, University of Monastir, Rue Avicenne, Monsastir 5019, Tunisia.
(2) Department of Biomedical and Biotechnological Sciences, University of Catania, Torre Biologica, Via Santa sofia n. 97, 95125 Catania, Italia.
(3) Department of Medical and Surgery Sciences, University of Catania, 95125, Via Santa sofia n. 78, 95123 Catania Italy.
(4) Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Piazza G. Ceasre, 11, 70124, Bari Italy.
Received: 10 February 2020; Accepted 17 March 2020; Published: 20 March 2020
The in vitro study examined in pheochromocytoma 12 (PC12) cells, whether the biomass form of Hericium erinaceus could exert a protective effect against oxidative stress and apoptosis induced by di(2-ethylhexyl) phthalate (DEHP), a plasticizer known to cause neurotoxicity. The researchers demonstrated that pre-treatment with Hericium erinaceus significantly reduced in force DHEP induced cell death. The researchers further postulated that the protective effect may be attributed to Hericium erinaceus´ ability in:
a) reducing intracellular reactive oxygen species levels,
b) preserving the activity of respiratory complexes and
c) stabilizing the mitochondrial membrane potential.
Additionally, Hericium erinaceus pre-treatment significantly modulated Nrf2 and Nrf2-dependent vitagenes expression, preventing the increase of pro-apoptotic and the decrease of anti-apoptotic markers. Collectively the data provides evidence of new preventive nutritional strategy using Hericium erinaceus against DHEP-induced apoptosis in PC12 cells.
Mycology Research Laboratories Ltd provided the Hericium erinaceus for this study.
Link to study
https://www.mdpi.com/1422-0067/21/6/2138
Clinical Articles
The following section outlines the clinical papers, posters and proposals that refer to the clinical use of MRL mushroom nutrition products. This information is for healthcare practitioners only and should not be provided to members of the general public.
Full Article
Clinical articles
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Mushroom Nutrition In Neurodegenerative Diseases
Prof. Vittorio Calabrese
Faculty of Medicine, University of Catania and University of Messina, Italy -
Targeting Neurogenesis with Mushroom Nutrition: A Mini Review
Dr. Elisabete Ferreiro, CNC-Center for Neuroscience and Cell Biology
CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal
Prof. Tito Fernandes, CIISA
Faculty of Veterinary Medicine, Lisbon University, Lisbon, Portugal -
Central Nervous System Profiling of Hericium erinaceus Biomass Powder by an Electropharmacogram Using Spectral Field Power in Conscious Freely Moving Rats
Prof. Wilfried Dimpfel Justus
Liebig-University Giessen, Germany
Dr. Julie Wiebe
Nektium Pharm S.L., Las Palmas, Spain
Dr. Nigel Gericke, Gericke Consulting
Baden, Switzerland
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A TCM Perspective on Mushroom Nutrition: Hericium erinaceus and Trametes versicolor (synn. Coriolus versicolor) as a synergistic combination
Karel Simonovsky and Zuzana Vancurikova