1) CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Portugal.
2) III-Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Portugal.
3) Institute of Pharmacology and Experimental Therapeutics/IBILLI, Faculty of Medicine, University of Coimbra, Portugal.
4) CNC,IBILLI-University of Coimbra, Coimbra, Portugal.
5) Achucarro Basque Center for Neuroscience, Science Park of the University of the Basque Country (UPV/EHU) Leioa, Spain
6) Ikerbasque Basque Foundation for Science, Bilbao, Spain.
7) Faculty of Pharmacy, University of Coimbra, Portugal.
8) Ministry of Education, Maputo, Mozambique
9) Faculty of Veterinary Medicine, Lisbon University, Portugal.
10) Department o of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Italy.
11) Institute of Biochemistry, Faculty of Medicine, University of Coimbra, Portugal.
This poster as presented on July 9 th, at the FENS 11 Meeting in Berlin, Germany.
Brain cognitive reserve refers to the ability f the brain to manage different challenges that arise throughout life, making it resilient lent to neuropathology. Hippocampal adult neurogenesis has been considered as a relevant contributor for brain cognitive reserve and brain plasticity. The production of adulty hippocampal neurons requires the continuous division of neural stem/progenitor cells, differentiation of newly-generated granule cells and their integration into the pre-existing circuits under specified extracellular conditions. This integration into the hippocampal circuitry relies on newly-formed dendritic branches of pre-matured neurons that reach the dentate gyrus (DG) molecular layer (ML).
Conclusions
1. Coriolus versicolor biomass oral administration promotes a significant increase in dendritic length and branching, and total dendritic volume of immature neurons, suggesting a positive effect on the hippocampal neurogenic reserve.
2. Increased beta-catenin levels in cytoplasm and nucleus of DG immature neurons suggests that Wnt/beta-catenin signalling plays an important role in CV positive effect on dendritic complexity of hippocampal newly-generated neurons.
3. This so far unexplored neurogenic potential of Coriolus versicolor supplementation emerges as a possible preventive strategy for different neurological conditions.
The Coriolus versicolor biomass was supplied by Mycology Research Laboratories Ltd. (Luton, UK).
Clinical Articles
The following section outlines the clinical papers, posters and proposals that refer to the clinical use of MRL mushroom nutrition products. This information is for healthcare practitioners only and should not be provided to members of the general public.
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Clinical articles
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Natural Compounds such as Hericium erinaceus and Coriolus versicolor Modulate Neuroinflammation, Oxidative Stress and Lipoxin A4 Expression in Rotenone-Induced Parkinson’s Disease in Mice
Marika Cordaro 1,†, Sergio Modafferi 2,†, Ramona D’Amico 3, Roberta Fusco 3, Tiziana Genovese 3, Alessio Filippo Peritore 3, Enrico Gugliandolo 4, Rosalia Crupi 4, Livia Interdonato 3, Davide Di Paola 3, Daniela Impellizzeri 3,*, Salvatore Cuzzocrea 3,5,*, Vittorio Calabrese 2,*, Rosanna Di Paola 4,‡ and Rosalba Siracusa 3,‡ -
Key Mechanisms and Potential Implications of Hericium erinaceus in NLRP3 Inflammasome Activation by Reactive Oxygen Species during Alzheimer’s Disease
Marika Cordaro 1,† , Angela Trovato Salinaro 2,† , Rosalba Siracusa 3,† , Ramona D’Amico 3 , Daniela Impellizzeri 3 , Maria Scuto 2 , Maria Laura Ontario 2, Salvatore Cuzzocrea 3 , Rosanna Di Paola 3,* , Roberta Fusco 3,‡ and Vittorio Calabrese 2,‡ -
Coriolus Versicolor Downregulates TLR4/NF-B Signaling Cascade in Dinitrobenzenesulfonic Acid-Treated Mice: A Possible Mechanism for the Anti-Colitis Effect
Daniela Impellizzeri 1,† , Roberta Fusco 2,† , Tiziana Genovese 1, Marika Cordaro 3 , Ramona D’Amico 1 , Angela Trovato Salinaro 4 , Maria Laura Ontario 4, Sergio Modafferi 4, Salvatore Cuzzocrea 1,5,* , Rosanna Di Paola 6,* , Vittorio Calabrese 4,‡ and Rosalba Siracusa 1,‡ -
Characterization of bioactive compounds in mushroom biomass of Coriolus versicolor, Hericium erinaceus and Pleurotus ostreatus species
Helena Araújo-Rodrigues, Manuela Amorim, Ana Sofia Salsinha, Sara Marçal, Freni K. Tavaria, João B. Relvas and Manuela E. Pintado. Catolica University, Porto Portugal. Presented at the XXII Congress, European Food ChMemistry Congress (EuroFoodChem) June 14-16, 2023, Belgrade, Serbia.