(1) Medical Center Clinical Institute for Reproductive Medicine, Pleven, Bulgaria
(2) Department of Dermatology and Venereology, UMHAT “Dr. Georgi Stranski”, Medical University, Pleven, Bulgaria
ABSTRACT — OBJECTIVE: Human papillomavirus (HPV) persistent infections of genital tract are strongly related to the development of genital warts and cellular transformation. These infections lead to different type of anogenital cancers, including cervical, vulvar and vaginal.
Current therapeutic treatments of genital warts include surgical removal, physician-applied and patient-applied treatments. Most of these treatments aim to remove the wart, with low effect on virus infectivity. Therefore, recurrence rate represents a significant issue that has not been yet addressed. Moreover, adverse events and patient discomfort hamper the potential of these treatments. The aim of our study was to present a protocol proposal for the treatment of primary and recurrent genital warts based on Coriolus-MRL and polyhexamethylene biguanide application (PHMB).
PATIENTS AND METHODS: 42 Patients with primary (15 patients) and recurrent (27 patients) genital warts were treated with the immunostimulator Coriolus-MRL and PHMB solution. Coriolus-MRL (Mycology Research Laboratories Ltd, Luton, Bedfordshire, United Kingdom) was administered as 2 tablets, 3 times per day, for six months while PHMB-gynaecological solution, a mono-dose gynaecological liquid-gel, was prepared and self-administered by patients before bedtime, every four days for twenty days and, afterward, every twenty days for the following six months. The control group was treated only with Coriolus-MRL, 2 tablets, 3 times per day, for six months. All patients with recurrent genital warts were previously treated with podophyllin local therapy.
CONCLUSIONS: These results have demonstrated that combined therapy with Coriolus-MRL and PHMB solution provide positive outcomes in cases of primary or recurrent genital warts.
Link to article:
https://www.ijmdat.com/article/220
Clinical Articles
The following section outlines the clinical papers, posters and proposals that refer to the clinical use of MRL mushroom nutrition products. This information is for healthcare practitioners only and should not be provided to members of the general public.
Full Article
Clinical articles
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Hericium Erinaceus Prevents DEHP-Induced Mitochondrial Dysfunction and Apoptosis in PC12 Cells
Ines Amara (1)(2), Maria Scuto (2), Agata Zappalà (2), Maria Laura Ontario (2), Antonio Petralia (3), Alwa Abid -Essefi (1), Luigi Maiolino (3), Anna Signorile (4), Angela Trovato Salinaro (2) and Vittorio Calabrese (2). -
Nutritional Mushroom Treatment in Meniere’s Disease with Coriolus versicolor: A Rationale for Therapeutic Intervention in Neuroinflammation and Antineurodegeneration
Maria Scuto (1),y , Paola Di Mauro (2),y, Maria Laura Ontario (1), Chiara Amato (2), Sergio Moda_eri (1), Domenico Ciavardelli (3,4), Angela Trovato Salinaro (1), Luigi Maiolino (2),* and Vittorio Calabrese (2) -
Evaluation of the prebiotic potential of Coriolus versicolor-Effect on the human gut microbiota.
C.M. Costa, S. Silva, L. Pimentel and M.M. Pintado -
Coriolus versicolor biomass increases dendritic arborization of newly generated neurons in mouse hippocampal dentate gyrus
Ferreiro E (1)(2)(3), Pita IR (4)(3), Mota SI (1)(2)(3), Valero J (5)(6), Ferreira NR (7), Fernandes T (8)(9), Calabrese V (10), Fontes-Ribeiro CA (4)(3), Pereira FC (4)(3), Rego AC (1)(3)(11)