(1) Medical Center Clinical Institute for Reproductive Medicine, Pleven, Bulgaria
(2) Department of Dermatology and Venereology, UMHAT “Dr. Georgi Stranski”, Medical University, Pleven, Bulgaria
ABSTRACT — OBJECTIVE: Human papillomavirus (HPV) persistent infections of genital tract are strongly related to the development of genital warts and cellular transformation. These infections lead to different type of anogenital cancers, including cervical, vulvar and vaginal.
Current therapeutic treatments of genital warts include surgical removal, physician-applied and patient-applied treatments. Most of these treatments aim to remove the wart, with low effect on virus infectivity. Therefore, recurrence rate represents a significant issue that has not been yet addressed. Moreover, adverse events and patient discomfort hamper the potential of these treatments. The aim of our study was to present a protocol proposal for the treatment of primary and recurrent genital warts based on Coriolus-MRL and polyhexamethylene biguanide application (PHMB).
PATIENTS AND METHODS: 42 Patients with primary (15 patients) and recurrent (27 patients) genital warts were treated with the immunostimulator Coriolus-MRL and PHMB solution. Coriolus-MRL (Mycology Research Laboratories Ltd, Luton, Bedfordshire, United Kingdom) was administered as 2 tablets, 3 times per day, for six months while PHMB-gynaecological solution, a mono-dose gynaecological liquid-gel, was prepared and self-administered by patients before bedtime, every four days for twenty days and, afterward, every twenty days for the following six months. The control group was treated only with Coriolus-MRL, 2 tablets, 3 times per day, for six months. All patients with recurrent genital warts were previously treated with podophyllin local therapy.
CONCLUSIONS: These results have demonstrated that combined therapy with Coriolus-MRL and PHMB solution provide positive outcomes in cases of primary or recurrent genital warts.
The Coriolus versicolor used in this preclinical study was supplied by Mycology Research Laboratories Ltd.
Link to article:
https://www.ijmdat.com/article/220
Clinical Articles
The following section outlines the clinical papers, posters and proposals that refer to the clinical use of MRL mushroom nutrition products. This information is for healthcare practitioners only and should not be provided to members of the general public.
Full Article
Clinical articles
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Bioaccessibility and Bioavailability of Bioactive Compounds from Mushroom Biomass Following in vitro Gastrointestinal Digestion presented at the CIPCA 2025 X International Conference on Food Proteins and Collides June 16-18, 2025 in Porto Portugal.
Helena Araújo-Rodrigues, Manuela Machado, João B. Relvas , Freni K. Tavaria, Manuela Pintado -
Neuroprotective Effects of Mushroom Biomass: Impact of Serum-Available and Gut Microbiota Metabolites in Caenorhabditis elegans Models of Alzheimer’s Disease. Presented on June 13th at the XXIII EURO FOODCHEM 2025 Conference in Bratislava, Slovakia
Helena Araújo-Rodrigues,Lidia Garzón-García, João B. Relvas, Freni K. Tavaria, Celestino Santos-Buelga, Ana M. González-Paramás, and Manuela E. Pintado -
Chemical Composition of Trametes versicolor, Hericium erinaceus, and Pleurotus ostreatus Mushroom Biomass: Deciphering their Rich α-glucan Composition and Nutritional Value
Helena Araújo-Rodrigues, Manuela Amorim, Clara Sousa, Ana Sofia Salsinha, Sara Marçal, Victor de Freitas, Joao Bettencourt Relvas, Freni K. Tavaria,Manuela E. Pintado. Journal of Food Composition and Analysis 143 (2025) 107612. -
Supporting Neurologic Health with Mushroom Nutrition
Victoria Bell, Palmen Dimitrov and Tito Fernandes