The main outcome was to study the mean rate of change in Natural Killer Cell Activity in patients who have undergone conventional breast cancer protocol: chemotherapy followed by radiotherapy in which there is a subseqent decrease in Natural Killer Cell Activity. The study was funded by CTRF and was halted as naturopaths were unable to recruit patients for the study. The attachments outline the rational for the study along with timeline.
Download the CTRF Clinical Study, click here.
Download the CTRF Clinical Timeline, click here.
Clinical Articles
The following section outlines the clinical papers, posters and proposals that refer to the clinical use of MRL mushroom nutrition products. This information is for healthcare practitioners only and should not be provided to members of the general public.
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Clinical articles
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Natural Compounds such as Hericium erinaceus and Coriolus versicolor Modulate Neuroinflammation, Oxidative Stress and Lipoxin A4 Expression in Rotenone-Induced Parkinson’s Disease in Mice
Marika Cordaro 1,†, Sergio Modafferi 2,†, Ramona D’Amico 3, Roberta Fusco 3, Tiziana Genovese 3, Alessio Filippo Peritore 3, Enrico Gugliandolo 4, Rosalia Crupi 4, Livia Interdonato 3, Davide Di Paola 3, Daniela Impellizzeri 3,*, Salvatore Cuzzocrea 3,5,*, Vittorio Calabrese 2,*, Rosanna Di Paola 4,‡ and Rosalba Siracusa 3,‡ -
Key Mechanisms and Potential Implications of Hericium erinaceus in NLRP3 Inflammasome Activation by Reactive Oxygen Species during Alzheimer’s Disease
Marika Cordaro 1,† , Angela Trovato Salinaro 2,† , Rosalba Siracusa 3,† , Ramona D’Amico 3 , Daniela Impellizzeri 3 , Maria Scuto 2 , Maria Laura Ontario 2, Salvatore Cuzzocrea 3 , Rosanna Di Paola 3,* , Roberta Fusco 3,‡ and Vittorio Calabrese 2,‡ -
Coriolus Versicolor Downregulates TLR4/NF-B Signaling Cascade in Dinitrobenzenesulfonic Acid-Treated Mice: A Possible Mechanism for the Anti-Colitis Effect
Daniela Impellizzeri 1,† , Roberta Fusco 2,† , Tiziana Genovese 1, Marika Cordaro 3 , Ramona D’Amico 1 , Angela Trovato Salinaro 4 , Maria Laura Ontario 4, Sergio Modafferi 4, Salvatore Cuzzocrea 1,5,* , Rosanna Di Paola 6,* , Vittorio Calabrese 4,‡ and Rosalba Siracusa 1,‡ -
Characterization of bioactive compounds in mushroom biomass of Coriolus versicolor, Hericium erinaceus and Pleurotus ostreatus species
Helena Araújo-Rodrigues, Manuela Amorim, Ana Sofia Salsinha, Sara Marçal, Freni K. Tavaria, João B. Relvas and Manuela E. Pintado. Catolica University, Porto Portugal. Presented at the XXII Congress, European Food ChMemistry Congress (EuroFoodChem) June 14-16, 2023, Belgrade, Serbia.